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Detection Medhodologies Of Covid-19 | Testings | New techs | Wit Biology

                          Detection Medhodologies Of Covid-19



       Where are we right now with testing well. We've come a long way and we still have a long way to go where we are right now is we are able to do well over a hundred thousand tests per day on Americans which is sufficient to test the high priority individuals those who are in the hospital those who are sick health care workers people in long-term care facilities first responders who are symptomatic. 



       We are not at a state nor will we be at a state in the near future where anyone who just wants a test or those who are mildly ill can get a test. We have hundreds of thousands a day in the next couple weeks, we will not have millions per day so we have sufficient testing to do what we need to do to affect patient care and to keep people safe. But it's going to be a few weeks before we're beyond that point Abbott has come out with a with a rapid test - you do a nasal swab and you know within 5 to 13 minutes. Whether you're positive is there any role for that I mean not in general is there any role for that. 
        
        But is there any role for that in augmenting the speed of knowing who has this and broadening who can get the test given that they say they can do 50,000 tests a day. Now the Abbott point of care test really very important and as you pointed out it's it's one of the only only a handful of tests and clearly the most disseminated that can get a positive result within four minutes and a negative result within 50 minutes. 

        Now they're going to produce 50,000 tests a day and that's a lot. But it's not five hundred thousand or five million. So what we're doing with this test is we would hope that those who really need an immediate result either for a clinical reason to go on a study protocol to know whether they're isolated in the ICU can get this sort of tests as well as individuals in very important epidemiologic investigations. 

        For example, a nursing home we know that nursing home mortality can be 30, 40, 50 percent. So it's very important to spot test people both to protect our seniors but also to know what seniors might be ill and can spread it so until this could be many hundreds of thousands per day. This is still a limited and very precious resource because we can get a result essentially immediately and there's no other test that can do that. 

        I want to switch back to the issue of how we test you gave me a notice of the idea that we were gonna have swabs that that could be self administered in other words nasal swabs that CDC was testing versus the more aggressive nasopharyngeal swab. Can you walk me through that how are we going to change how we're going to approach testing swab wise in order to decrease the need for PPE at a time.     
        When we need it in the hospital's you are exactly 100 percent correct the self swab really is something that isn't it's a critical breakthrough because as you pointed out it does not need to be administered by a healthcare provider like the nasopharyngeal swabs and when that healthcare provider does a nasopharyngeal swab they have to change PPE between each test and the exact fact is we calculated this early on is that if we really wanted to have widespread testing consistent with the capability that we had even two weeks ago. 

         We would have blown eighty percent as a strategic national stockpile in the first two weeks just on testing and obviously that is unconscionable. Because people need the PPE in the hospitals. So this nasal swab was so important to me and to our teams and United Health Group out on the west coast with the Gates Foundation really did the validation study to submit to the FDA it allows at the community based testing, which you know is a little bit invasive and there's no PPE. So we think this is really important to the next phase of testing.



         The Immunological testing something we call analyzer which is an exciting test it's an immunoassay. I wanted you to talk to what the goal of that would be in terms of knowing whose immune maybe knowing who has a recent infection. If it's an IgM what walk me through how that test would be useful to us right now. So first of all we're still working to finalize the concepts of how this would be employed,  but this is the working hypothesis sort of right off the press.

          We for epidemiologic reasons we need to know how many people were infected and you can't really know that because there are so many asymptomatic infections that even if we had all the tests that we could people wouldn't come to be tested and you can't test 300 million people the second important component is it would be really fantastic to have sort of a digital immunity passport that could be protected health information that you can carry that. 

          For example if you're a healthcare worker in a long-term facility that we know wherever you go you're certified immune right and if this test can show that you have IgG and as we expect that the IgG will correlate with immunity and that needs to be absolutely proven right that, if you have an IgG you're not shedding virus and we're working on that right now. But if you had that then essentially we would know that for example you could not contract the virus and spread it to long term care facilities or the elderly do you see a point of care. 

          Where you have the the the PCR test and then you have the the serological tests. One for active infection, the other one for you know antibodies to took over nineteen. I think we will have very hot very user-friendly quote pregnancy test like abilities that can be done within a couple of minutes to show your immunity. We will have point-of-care testing to show if you're infected currently in shedding virus again not so scalable think of the Abbott Machine fifty thousand a day not five million a day and in the future we will have a vaccine that you know is twelve to eighteen months away. 

          So are you know this looks good coming together and it's gonna come together soon, but it's not together now you know this is a brand new virus the world has never seen with unforeseen challenges and you know right now. We are focused on making sure that people who need testing who have a difference in their therapies or could transmit the virus to needy populations all get tested. 



          We can do that we cannot do a lot more than that and I want people to be realistic about that we've come a long way but that's where we are in secondly making sure, we meet the clinical needs with ventilators hydroxychloroquine all the kind of things that will save lives today tomorrow and over the next couple of weeks. But the next station we just talked about is coming very soon. 

           Do you think we can transition as a society to using testing to some extent to either augment or to replace the need for isolation, so of course you're 100% correct and this is a difficult question but I think the answer is yes. This is not an on or off switch right we're not going to be in the middle of the pandemic and then we're going to be out of the pandemic completely. There was going to be transition times on the country doesn't open up doesn't closed down and open up all with the light switch. It is clear that we're going to need to get critical industries including healthcare industries back on their feet and back working and during that transition time out of this or potentially into the next wave. 

          We are going to need a combination of serologic testing for immunity plus active testing to for those who are asymptomatic on that that you know it's messy, it's not clean, it's not perfect, it's not black and white. But that is reality right. Life biology medicine is not so simple so I agree with you completely during the transition out of this and potentially during the transition into a next phase that kind of combination is really important it can't be done for 300 million people, but certainly for healthcare workers and critical industries I think there's a combination I think it's going to have to happen no question whatsoever in my mind... 

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